Formulated with a high-potency blend of bioactive B vitamins, key methyl donors, and supportive amino acids designed to optimize methylation, homocysteine metabolism, and cellular detoxification.

B vitamins are essential for hundreds of daily processes in the body, from producing energy and neurotransmitters to supporting digestion, detoxification, and hormonal balance. 

This formula provides methylated and phosphorylated forms—5-MTHF (Quatrefolic®), methylcobalamin (B12), pyridoxal-5-phosphate (B6), and riboflavin-5-phosphate (B2)—alongside trimethylglycine (TMG) and L-serine to deliver essential cofactors for those with increased methylation needs, sluggish detox pathways, or compromised nutrient absorption.

MethylB+ is ideal for anyone looking to support foundational health—particularly those experiencing fatigue, brain fog, mood imbalances, digestive issues, or elevated homocysteine levels. Due to its potency, we recommend starting with a lower dose—especially if you have MTHFR, COMT, or other methylation-related gene variants, or if you’ve experienced sensitivity to methylated nutrients. In some cases, it may be helpful to test for MTHFR, COMT, or MAOA polymorphisms, or work with a practitioner to determine if this formula is right for you.*